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Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone Suspension and Tasigna

Determining the interaction of Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone Suspension and Tasigna and the possibility of their joint administration.

Check result:

Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone Suspension <> Tasigna

Relevance: 24.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Taking the nilotinib and aluminum hydroxide doses too close together may interfere with the absorption of nilotinib and reduce its effectiveness. To prevent or minimize the interaction, nilotinib and aluminum hydroxide dosing should be separated by at least two hours. Contact your doctor if your condition worsens. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Antacids significantly decrease the oral bioavailability of nilotinib. The mechanism is decreased solubility of nilotinib due to antacid-induced gastric pH increases. Nilotinib's solubility is pH-dependent and it is insoluble at a pH of 4.5 or higher.

MANAGEMENT: Patients treated with nilotinib should not take antacids or other agents with acid-neutralizing effects for at least 2 hours before or 2 hours after a nilotinib dose.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0

Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone Suspension

Generic Name: aluminum hydroxide / magnesium hydroxide / simethicone

Brand name: Almacone, Gelusil, Mag-al Plus, Mi-Acid, Milantex, Mintox, Mylanta Maximum Strength, Rulox, Mylanta Fast Acting, Mylanta DS Fast Acting, Maalox Plus, Masanti DS, Masanti II, Masanti, Alamag Plus, Mi-Acid II, Almacone-2, Mintox Plus, Mylagen, Mylagen-II, Magaant, Ri-Mox Plus, Rulox Plus, Di-Gel, Ri-Gel II, Uni-Lan, Uni-Lan II, Urban, Urban DS, Maldroxal Plus, Maalox Plus Extra Strength, Tempo, Mylanta, Maalox Max, Maalox, Aldroxicon I, Aldroxicon II, Maalox Antacid Antigas Regular Strength, Mintox Extra Strength, Mintox Maximum Strength, Comfort Gel Original, Comfort Gel Extra Strength, Mylanta Maximum Strength Cherry, Maalox Max Wild Berry, Maalox Advanced Maximum Strength, Milantex Maximum Strength, Maalox Advanced Regular Strength, Geri-Lanta, Mag-al Plus XS, Mylanta Maximum Strength Vanilla Caramel, Mi-Acid Maximum Strength, Di-Gel Liquid

Synonyms: Aluminum hydroxide, magnesium hydroxide, and simethicone

What is Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone Suspension?

Tasigna

Generic Name: nilotinib

Brand name: Tasigna

Synonyms: n.a.

What is Tasigna?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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