Amphotericin b liposome Intravenous and Flucytosine

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using flucytosine together with amphotericin B liposomal may increase the effects of flucytosine. Contact your doctor if you experience nausea, vomiting, diarrhea, abdominal pain, and yellowing of the skin or eyes, If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Concomitant use of amphotericin B may potentiate the toxicity of flucytosine. The exact mechanism of interaction is unknown but may involve increased cellular uptake of flucytosine or impairment of its renal excretion. The risk of gastrointestinal, hepatic, and hematologic toxicity may be increased.

MANAGEMENT: Caution is advised if flucytosine must be used in patients who are receiving treatment with amphotericin. Blood levels should be monitored and the dose or dosing interval should be adjusted to maintain flucytosine concentrations below 100 mcg/mL.

Amphotericin b liposome Intravenous

Generic Name: amphotericin b liposomal

Brand name: Ambisome

Synonyms: Amphotericin B liposomal, Amphotericin B (Liposomal)

What is Amphotericin b liposome Intravenous?

Flucytosine

Generic Name: flucytosine

Brand name: Ancobon

Synonyms: n.a.

What is Flucytosine?