BCG intravesical and Hexaminolevulinate Urinary bladder

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Before you undergo any imaging procedure where hexaminolevulinate may be used, let your doctor know if you have received BCG within the past 90 days. Recent use of BCG may put you at risk for bladder inflammation, which can lead to false-positive results as well as increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Inflammation of bladder resulting from the use of BCG immunotherapy or intravesical chemotherapy may interfere with the diagnostic utility of hexaminolevulinate, which is an ester of the heme precursor, aminolevulinic acid. Following intravesical instillation of hexaminolevulinate, photoactive porphyrins are formed and accumulate intracellularly in bladder wall lesions. In humans, a higher degree of accumulation of porphyrins has been demonstrated in neoplastic or inflamed cells compared to normal bladder urothelium. As such, inflammation may lead to increased porphyrin buildup and higher risk of local toxicity upon illumination as well as false-positive fluorescence.

MANAGEMENT: The use of hexaminolevulinate is considered contraindicated in patients given BCG immunotherapy or intravesical chemotherapy within the past 90 days due to a high risk of bladder inflammation in these patients. Widespread inflammation of the bladder should be excluded by cystoscopy before hexaminolevulinate is administered. If a widespread inflammation in the bladder becomes evident during white light inspection, the blue light inspection should be avoided.

BCG intravesical

Generic Name: bcg

Brand name: Tice BCG Live, Tice BCG Vaccine, Theracys 3, TheraCys, BCG vaccine, Tice BCG

Synonyms: BCG (Intravesical)

What is BCG intravesical?

Hexaminolevulinate Urinary bladder

Generic Name: hexaminolevulinate

Brand name: Cysview

Synonyms: Hexaminolevulinate

What is Hexaminolevulinate Urinary bladder?