Betamethasone Sodium Phosphate and Betamethasone Acetate and Versed injection
Determining the interaction of Betamethasone Sodium Phosphate and Betamethasone Acetate and Versed injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Certain corticosteroids may decrease the plasma concentration of some benzodiazepines. Limited data are available for midazolam and triazolam. The mechanism is related to induction of hepatic cytochrome P450 enzymes responsible for benzodiazepine metabolism. The clinical significance may depend on the dosage and duration of corticosteroid therapy and be of greater importance with oral administration of benzodiazepines.
- Villikka K, Kivisto KT, Neuvonen PJ "The effect of dexamethasone on the pharmacokinetics of triazolam." Pharmacol Toxicol 83 (1998): 135-8
- Nakajima M, Suzuki T, Sasaki T, Yokoi T, Hosoyamada A, Yamamoto T, Kuroiwa Y "Effects of chronic administration of glucocorticoid on midazolam pharmacokinetics in humans." Ther Drug Monit 21 (1999): 507-13
Generic Name: betamethasone
Brand name: Celestone Soluspan, Celestone, Celestone Phosphate, Selestoject, Cell-U-Jec, Adbeon, Beta-Phos/AC
Synonyms: Betamethasone (injection), Betamethasone (Systemic)
Generic Name: midazolam
Brand name: Versed, Nayzilam
Synonyms: Versed
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Betamethasone Sodium Phosphate and Betamethasone Acetate-Versiclear
- Betamethasone Sodium Phosphate and Betamethasone Acetate-Verteporfin
- Betamethasone Sodium Phosphate and Betamethasone Acetate-Verteporfin Intravenous, Injection
- Betamethasone Sodium Phosphate and Betamethasone Acetate-Verzenio
- Betamethasone Sodium Phosphate and Betamethasone Acetate-Vesanoid
- Betamethasone Sodium Phosphate and Betamethasone Acetate-VESIcare
- Versed injection-Betamethasone sodium phosphate and betamethasone acetate Injection
- Versed injection-Betamethasone Spray
- Versed injection-Betamethasone topical
- Versed injection-Betamethasone Valerate
- Versed injection-Betamethasone Valerate Foam
- Versed injection-Betamethasone Valerate Lotion