Busulfan and Children’s Tylenol Plus
Determining the interaction of Busulfan and Children’s Tylenol Plus and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using acetaminophen together with busulfan may increase the effects of busulfan. If your doctor prescribes these two drugs, you may need a dose adjustment or special tests to safely use both. Contact your doctor if you notice any of the side effects of busulfan, which may include bleeding or bruising, seizures, fever or chills, persistent cough, congestion, or breathing problems. You may also notice pain in the stomach or back, nausea, vomiting, or diarrhea. Also, these can be accompanied by decreased appetite or weight loss. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Theoretically, coadministration with acetaminophen may increase the plasma concentrations of busulfan. The proposed mechanism is decreased busulfan clearance via conjugation due to reduced levels of glutathione in blood and tissues caused by acetaminophen.
MANAGEMENT: Patients receiving busulfan therapy should be monitored more closely for toxicity (e.g., myelosuppression, seizures) if acetaminophen is administered concurrently. When busulfan is administered intravenously, acetaminophen should preferably be avoided within 72 hours prior to and during infusion of busulfan to minimize risk of an interaction.
- "Product Information. Busulfex (busulfan)." ESP Pharma Inc, Edison, NJ.
Generic Name: busulfan
Brand name: Busulfex, Myleran
Synonyms: Busulfan (oral/injection)
Generic Name: acetaminophen / dextromethorphan
Brand name: Children's Triacting, Triaminic Cough & Sore Throat, Triaminic Cough & Sore Throat Softchews, Tylenol Childrens Plus Cough & Sore Throat, Tylenol Cough, Drixoral Cough/Sore Throat, Tylenol Cough and Sore Throat Daytime, Children's Tylenol Cold + Cough + Sore Throat, Children's Triaminic Cough and Sore Throat, Childrenâs Tylenol Plus, Triaminic Cough/Sore Throat, Tylenol Cough/Sore Throat
Synonyms: Acetaminophen and dextromethorphan
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Busulfan-ChiRhoStim
- Busulfan-Chlo Hist
- Busulfan-Chlo Tuss (Chlophedianol/Dexbrompheniramine/Phenylephrine Liquid)
- Busulfan-Chlo Tuss (Pseudoephedrine, Dexbrompheniramine, and Chlophedianol Liquid)
- Busulfan-Chlo Tuss EX
- Busulfan-Chlo-Amine
- Children’s Tylenol Plus-Busulfan Concentrate Injection
- Children’s Tylenol Plus-Busulfan Injection
- Children’s Tylenol Plus-Busulfan Intravenous
- Children’s Tylenol Plus-Busulfan oral/injection
- Children’s Tylenol Plus-Busulfan Tablet
- Children’s Tylenol Plus-Busulfex