Caffeine Capsules and Tablets and Topotecan Intravenous
Determining the interaction of Caffeine Capsules and Tablets and Topotecan Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:The cytotoxic and cytostatic activity of topotecan may be diminished in the presence of caffeine. The mechanism is probably formation of complexes between caffeine and topotecan which result in reducing the effective concentration of the free form of topotecan. The clinical implications of this interaction are unknown.
- Traganos F, Kapuscinski J, Gong J, Ardelt B, Darzynkiewicz RJ, Darzynkiewicz Z "Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells." Cancer Res 53 (1993): 4613-8
Generic Name: caffeine
Brand name: NoDoz, Vivarin, Cafcit
Synonyms: Caffeine
Generic Name: topotecan
Brand name: Hycamtin
Synonyms: Topotecan (oral/injection), Topotecan
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Caffeine Capsules and Tablets-Topotecan oral/injection
- Caffeine Capsules and Tablets-Toprol XL
- Caffeine Capsules and Tablets-Topsyn
- Caffeine Capsules and Tablets-Toradol
- Caffeine Capsules and Tablets-Toradol (Ketorolac Injection)
- Caffeine Capsules and Tablets-Toradol (Ketorolac Tablets)
- Topotecan Intravenous-Caffeine Citrate
- Topotecan Intravenous-Caffeine Citrate Injection Solution
- Topotecan Intravenous-Caffeine citrate Intravenous
- Topotecan Intravenous-Caffeine Citrate Oral Solution
- Topotecan Intravenous-Caffeine; Caffeine and Sodium Benzoate Injection; Caffeine Citrate
- Topotecan Intravenous-Cal-Glu (Calcium Gluconate Capsules and Tablets)