Carbidopa and Levodopa ODT and Fosphenytoin Injection
Determining the interaction of Carbidopa and Levodopa ODT and Fosphenytoin Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using fosphenytoin together with levodopa may decrease the effects of levodopa. Contact your doctor if your condition changes or if you experience a worsening of your parkinsonian symptoms. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Phenytoin may decrease the therapeutic effects of levodopa. One small study has suggested that administration of phenytoin may exacerbate the rigidity and hypokinesia of patients with Parkinson's disease. The mechanism of this interaction is not known.
MANAGEMENT: If phenytoin and levodopa must be used together, close observation for evidence of altered levodopa effects is recommended. Patients should be advised to notify their physician if they experience a worsening of their parkinsonian symptoms. Levodopa dosage increases or alternatives to phenytoin may be required if evidence of an interaction is observed.
- Mendez JS, Cotzias GC, Mena I, Papavasiliou PS "Diphenylhydantoin. Blocking of levodopa effects." Arch Neurol 32 (1975): 44-6
Generic Name: carbidopa / levodopa
Brand name: Parcopa, Rytary, Sinemet, Sinemet CR, Duopa
Synonyms: Carbidopa and levodopa, Carbidopa and Levodopa
Generic Name: fosphenytoin
Brand name: Cerebyx
Synonyms: Fosphenytoin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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