Chloromycetin Oral, Intravenous, Injection and Coumadin Injection
Determining the interaction of Chloromycetin Oral, Intravenous, Injection and Coumadin Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using chloramphenicol together with warfarin, this can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Chloramphenicol may significantly increase the effects of oral anticoagulants. The proposed mechanism is inhibition of hepatic metabolism. Patients with vitamin K deficiencies may have a higher risk.
MANAGEMENT: These drugs should only be given concomitantly if benefit outweighs risk. If patients do receive this combination, they should be monitored for bleeding, the INR or prothrombin time should be monitored closely, and warfarin dosage should be decreased as necessary. Patients should be advised to promptly report any signs of unusual bleeding or bruising to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, vaginal bleeding, nosebleeds, bleeding of gums from brushing, red or brown urine, or red or black stools.
- Christensen LK, Skovsted L "Inhibition of drug metabolism by chloramphenicol." Lancet 2 (1969): 1397-9
- Ku LL, Ward CO, Durgin SJ "A clinical study of drug interaction and anticoagulant therapy." Drug Intell Clin Pharm 4 (1970): 300-6
- Udall JA "Human sources and absorption of vitamin K in relation to anticoagulation stability." JAMA 194 (1965): 107-9
- Yacobi A, et al "Pharmacokinetics and pharmacodynamic studies of acute interaction between warfarin enantiomers and chloramphenicol in rats." J Pharmacol Exp Ther 231 (1984): 80-4
- Koch-Weser J, Sellers EM "Drug interactions with coumarin anticoagulants (second of two parts)." N Engl J Med 285 (1971): 547-58
- Matsaniotis J, Messaritakis J, Vlachou C "Hypoprothrombinaemic bleeding in infants associated with diarrhoea and antibiotics." Arch Dis Child 45 (1970): 586-7
- Ambrose PJ "Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate." Clin Pharmacokinet 9 (1984): 222-38
Generic Name: chloramphenicol
Brand name:
Synonyms: Chloromycetin
Generic Name: warfarin
Brand name: Coumadin, Jantoven
Synonyms: Coumadin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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