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Cimetidine Injection and Quetiapine

Determining the interaction of Cimetidine Injection and Quetiapine and the possibility of their joint administration.

Check result:
Cimetidine Injection <> Quetiapine
Relevance: 21.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Cimetidine has been reported to decrease the clearance of quetiapine by 20%. The mechanism of the interaction is unknown. No dosage adjustment appears necessary, however, clinical monitoring for altered quetiapine effect is recommended if cimetidine is started or stopped in a patient stabilized on quetiapine. Patients should be advised to notify their physician if they experience symptoms of possible toxicity, including excessive drowsiness or sedation, fast or irregular heartbeat, dizziness, syncope, or extrapyramidal symptoms (uncontrolled movements of the tongue, mouth, or extremities).

References
  • "Product Information. Seroquel (quetiapine)." Zeneca Pharmaceuticals, Wilmington, DE.
Cimetidine Injection

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

Quetiapine

Generic Name: quetiapine

Brand name: Seroquel, Seroquel XR

Synonyms: QUEtiapine

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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