Clotrimazole Mucous membrane, oral and Donepezil Hydrochloride
Determining the interaction of Clotrimazole Mucous membrane, oral and Donepezil Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 2D6 and/or 3A4 may increase the plasma concentrations of donepezil, which is primarily metabolized by these isoenzymes. In a 7-day crossover study in 18 healthy volunteers, the potent CYP450 3A4 inhibitor ketoconazole (200 mg once daily) increased the mean peak plasma concentration (Cmax) and systemic exposure (AUC) of donepezil (5 mg once daily) by approximately 36% each. The clinical relevance of these increases is unknown.
- "Product Information. Aricept (donepezil)." Pfizer US Pharmaceuticals, New York, NY.
- Rojas-Fernandez C, Fisher C "Drug interactions and donepezil." J Am Geriat Soc 40 (2000): 597-8
- Tiseo PJ, Perdomo CA, Friedhoff LT "Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses." Br J Clin Pharmacol 46 (1998): 30-4
Generic Name: clotrimazole
Brand name: Mycelex Troche
Synonyms: Clotrimazole, Clotrimazole (Oral)
Generic Name: donepezil
Brand name: Aricept, Aricept ODT
Synonyms: Donepezil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Clotrimazole Mucous membrane, oral-Donepezil Orally Disintegrating Tablet
- Clotrimazole Mucous membrane, oral-Donepezil Orally Disintegrating Tablets
- Clotrimazole Mucous membrane, oral-Donepezil Tablets
- Clotrimazole Mucous membrane, oral-Dong quai
- Clotrimazole Mucous membrane, oral-Donnatal
- Clotrimazole Mucous membrane, oral-Donnatal (Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir)
- Donepezil Hydrochloride-Clove
- Donepezil Hydrochloride-Clovique
- Donepezil Hydrochloride-Cloxacillin Capsules
- Donepezil Hydrochloride-Cloxacillin Suspension
- Donepezil Hydrochloride-Cloxapen
- Donepezil Hydrochloride-Clozapine