Colesevelam Oral Suspension and Coumadin Injection
Determining the interaction of Colesevelam Oral Suspension and Coumadin Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Colesevelam may reduce the blood-thinning effects of warfarin. You may need a dose adjustment and/or more frequent monitoring of your INR to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Decreases in International Normalized Ratio (INR) have been reported during postmarketing use of colesevelam in patients receiving warfarin. The mechanism of interaction is unknown. In an in vivo drug interaction study, colesevelam had no effect on warfarin bioavailability during coadministration. However, the study did not evaluate warfarin pharmacodynamics.
MONITOR: Bile acid sequestrants can decrease the absorption of fat-soluble vitamins like vitamin K, which may theoretically interfere with the pharmacologic effects of warfarin and similar anticoagulants. No specific studies have been conducted to evaluate potential effects of colesevelam on the absorption of coadministered dietary or supplemental vitamins. In nonclinical safety studies, rats administered colesevelam at doses greater than 30-fold the projected human clinical dose developed hemorrhage in association with vitamin K deficiency.
MANAGEMENT: Patients receiving warfarin and other oral anticoagulants should have INR monitored frequently during initiation of colesevelam, then periodically thereafter.
- "Product Information. Welchol (colesevelam)" Daiichi Sankyo, Inc., Parsippany, NJ.
- Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
Generic Name: colesevelam
Brand name: Welchol, Colesevelam Hydrochloride
Synonyms: Colesevelam
Generic Name: warfarin
Brand name: Coumadin, Jantoven
Synonyms: Coumadin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Colesevelam Oral Suspension-Covaryx
- Colesevelam Oral Suspension-Covaryx HS
- Colesevelam Oral Suspension-Covera-HS
- Colesevelam Oral Suspension-Cozaar
- Colesevelam Oral Suspension-CPB WC
- Colesevelam Oral Suspension-CPM-PSE DM Drops
- Coumadin Injection-Colesevelam Tablets
- Coumadin Injection-Colestid
- Coumadin Injection-Colestid (Colestipol Granules)
- Coumadin Injection-Colestid (Colestipol Tablets)
- Coumadin Injection-Colestid Flavored
- Coumadin Injection-Colestid Oral Suspension