Colesevelam Tablets and SuperiorSource K1
Determining the interaction of Colesevelam Tablets and SuperiorSource K1 and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using colesevelam together with phytonadione may decrease the effects of phytonadione. Phytonadione should be administered at least 4 hours before colesevelam. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies, rats administered colesevelam at doses greater than 30-fold the projected human clinical dose developed hemorrhage in association with vitamin K deficiency. In a crossover study involving healthy subjects, coadministration of sevelamer with calcitriol resulted in a significant reduction in bioavailability for calcitriol (calcitriol with sevelamer vs calcitriol alone: AUC 137 pg*h/mL vs 318 pg*h/mL and Cmax 40.1 pg/mL vs 49.7 pg/mL, respectively).
MANAGEMENT: Oral vitamin supplements should be administered at least 4 hours before colesevelam and either 1 hour before or 4 to 6 hours after other bile acid sequestrants and sevelamer.
- Peirce D, Hossack S, Poole L, et.al "The effect of sevelamer carbonate and lanthanum carbonate on the pharmacokinetics of oral calcitriol." Nephrol Dial Transplant 26 (2011): 1615-21
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Rocaltrol (calcitriol)." Roche Laboratories, Nutley, NJ.
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Welchol (colesevelam)" Daiichi Sankyo, Inc., Parsippany, NJ.
Generic Name: colesevelam
Brand name: Welchol, Colesevelam Hydrochloride
Synonyms: Colesevelam
Generic Name: phytonadione
Brand name: Aquamephyton, Konakion, Mephyton, Vitamin K1
Synonyms: Phytonadione (oral/injection), Phytonadione
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Colesevelam Tablets-Supervite
- Colesevelam Tablets-Suphedrin
- Colesevelam Tablets-Suphedrine
- Colesevelam Tablets-Suphera
- Colesevelam Tablets-Suplevit
- Colesevelam Tablets-Supprelin-LA
- SuperiorSource K1-Colestid
- SuperiorSource K1-Colestid (Colestipol Granules)
- SuperiorSource K1-Colestid (Colestipol Tablets)
- SuperiorSource K1-Colestid Flavored
- SuperiorSource K1-Colestid Oral Suspension
- SuperiorSource K1-Colestipol