Cordarone injection and Members Mark Loratadine

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using amiodarone together with loratadine can affect the rhythm of your heart. Call your doctor if you have symptoms of irregular heartbeat, chest tightness, blurred vision or nausea. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: QT interval prolongation and torsade de pointes have been reported with the coadministration of loratadine and amiodarone. A 73-year-old woman receiving chronic therapy with amiodarone developed syncope and multiple episodes of torsade de pointes following the addition of loratadine. The exact mechanism of interaction is unknown. Although QT interval prolongation and torsade de pointes are known adverse effects of amiodarone, they have not been associated with loratadine. It is possible that loratadine competitively inhibits the metabolism of amiodarone via CYP450 3A4, since both are substrates of the isoenzyme.

MANAGEMENT: Until more information is available, it may be appropriate to monitor QT interval whenever loratadine is coadministered with amiodarone. Patients should be advised to seek medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, palpitations, or syncope.

Cordarone injection

Generic Name: amiodarone

Brand name: Cordarone, Pacerone, Nexterone

Synonyms: Cordarone

What is Cordarone injection?

Members Mark Loratadine

Generic Name: loratadine

Brand name: Alavert, Claritin, Claritin Reditab, Clear-Atadine, Dimetapp ND, Ohm Allergy Relief, QlearQuil All Day & Night, Tavist ND, Wal-itin

Synonyms: Loratadine

What is Members Mark Loratadine?