Coumadin and Propulsid (Cisapride Suspension)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Cisapride is no longer on the market in the US. Do not take cisapride with any other medication.

MONITOR: Cisapride may enhance the effects of oral anticoagulants. The mechanism is unknown. Increases in coagulation times have been reported following the initiation of cisapride therapy in patients stabilized on anticoagulant therapy. However, other studies have reported increased warfarin requirements in patients taking cisapride.

MANAGEMENT: It is recommended that the INR or PT be monitored if cisapride is added, cisapride is discontinued, or the dosage is adjusted in a patient receiving anticoagulants. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.

Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Coumadin?

Propulsid (Cisapride Suspension)

Generic Name: cisapride

Brand name: Propulsid

Synonyms: Propulsid (Suspension), Propulsid

What is Propulsid (Cisapride Suspension)?