Coumadin Injection and Ethmozine
Determining the interaction of Coumadin Injection and Ethmozine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:According to one case report, prothrombin time was elevated in a patient who was stable on warfarin and who then received moricizine. Controlled studies, however, have revealed only that serum warfarin half-life is decreased during coadministration. These studies have found no significant change in the prothrombin time. Similar effects may occur with other oral anticoagulants. Management consists of following the patient's prothrombin time or INR during coadministration. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
- Serpa MD, Cossolias J, McGreevy MJ "Moricizine-warfarin: a possible drug interaction." Ann Pharmacother 26 (1992): 127
- Benedek IH, King SY, Powell RJ, et al "Effect of moricizine on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers." J Clin Pharmacol 32 (1992): 558-63
Generic Name: warfarin
Brand name: Coumadin, Jantoven
Synonyms: Coumadin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Coumadin Injection-Ethosuximide
- Coumadin Injection-Ethosuximide Capsules
- Coumadin Injection-Ethosuximide Oral Solution
- Coumadin Injection-Ethosuximide Solution
- Coumadin Injection-Ethosuximide Syrup
- Coumadin Injection-Ethotoin
- Ethmozine-Covaryx
- Ethmozine-Covaryx HS
- Ethmozine-Covera-HS
- Ethmozine-Cozaar
- Ethmozine-CPB WC
- Ethmozine-CPM-PSE DM Drops