Coumadin Injection and Fluvastatin Sodium
Determining the interaction of Coumadin Injection and Fluvastatin Sodium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Fluvastatin has been reported to increase the hypoprothrombinemic effect of warfarin. INR was altered, but no clinical bleeding occurred. A similar interaction has been reported for lovastatin and in some cases has led to clinically significant bleeding. It is recommended that the clinician monitor more closely for signs of bleeding if fluvastatin is started, fluvastatin is discontinued, or the dosage is changed while a patient is also taking oral anticoagulants. Pravastatin has not been shown to interact with warfarin.
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- Trilli LE, Kelley CL, Aspinall SL, Kroner BA "Potential interaction between warfarin and fluvastatin." Ann Pharmacother 30 (1996): 1399-402
- Thijssen HH, Flin ois JP, Beaune PH "Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes." Drug Metab Dispos 28 (2000): 1284-90
- Kline SS, Harrell CC "Potential warfarin-fluvastatin interaction." Ann Pharmacother 31 (1997): 790
- Trilli LE, Kelley CL, Aspinall SL, Kroner BA "Potential interaction between warfarin and fluvastatin." Ann Pharmacother 30 (1996): 1399-402
- "Product Information. Lescol (fluvastatin)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: warfarin
Brand name: Coumadin, Jantoven
Synonyms: Coumadin
Generic Name: fluvastatin
Brand name: Lescol, Lescol XL
Synonyms: Fluvastatin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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