Coumadin Injection and Tamoxifen
Determining the interaction of Coumadin Injection and Tamoxifen and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using tamoxifen together with warfarin. Combining these medications may significantly increase the effects of warfarin and cause you to bleed more easily. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring of your INR to safely use both medications. Call your doctor immediately if you experience any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:CONTRAINDICATED: Tamoxifen may enhance the hypoprothrombinemic effects of warfarin and other similar anticoagulants. The mechanism of interaction has not been established. Significant increases in prothrombin time or INR as well as severe and fatal bleeding complications have been reported. In some cases, a substantial reduction in anticoagulant dose was required.
MANAGEMENT: The use of tamoxifen is considered contraindicated in women who require concomitant coumarin-type anticoagulants or in women with a history of deep vein thrombosis or pulmonary embolus. Where such coadministration exists, careful monitoring of the INR is recommended.
- "Product Information. Nolvadex (tamoxifen)." Zeneca Pharmaceuticals, Wilmington, DE.
- Ritchie LD, Grant SM "Tamoxifen-warfarin interaction: the Aberdeen hospitals drug file." BMJ 298 (1989): 1253
- "Product Information. Fareston (toremifene)." Schering Laboratories, Kenilworth, NJ.
- Lodwick R, McConkey B, Brown AM, Beeley L "Life threatening interaction between tamoxifen and warfarin." Br Med J 295 (1987): 1141
- Tenni P, Lalich DL, Byrne MJ "Life threatening interaction between tamoxifen and warfarin." BMJ 298 (1989): 93
Generic Name: warfarin
Brand name: Coumadin, Jantoven
Synonyms: Coumadin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Coumadin Injection-Tamoxifen Citrate
- Coumadin Injection-Tamoxifen Solution
- Coumadin Injection-Tamoxifen Tablets
- Coumadin Injection-Tamsulosin
- Coumadin Injection-Tamsulosin Capsules
- Coumadin Injection-Tamsulosin Hydrochloride
- Tamoxifen-Covaryx
- Tamoxifen-Covaryx HS
- Tamoxifen-Covera-HS
- Tamoxifen-Cozaar
- Tamoxifen-CPB WC
- Tamoxifen-CPM-PSE DM Drops