Coumadin Injection and Topiramate Extended-Release Capsules
Determining the interaction of Coumadin Injection and Topiramate Extended-Release Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with topiramate may decrease the anticoagulant effects of vitamin K antagonists (VKAs). The mechanism has not been delineated. MANAGEMENT: Until more information is available, patients receiving VKAs with topiramate should be closely monitored during concomitant therapy. The prothrombin time (PT) or International Normalized Ratio (INR) should be checked frequently and the VKA dosage adjusted accordingly, particularly following initiation, change of dosage, or discontinuation of topiramate therapy. References Cerner Multum, Inc. "Australian Product Information." O 0 Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Professional:MONITOR: Coadministration with topiramate may decrease the anticoagulant effects of vitamin K antagonists (VKAs). The mechanism has not been delineated.
MANAGEMENT: Until more information is available, patients receiving VKAs with topiramate should be closely monitored during concomitant therapy. The prothrombin time (PT) or International Normalized Ratio (INR) should be checked frequently and the VKA dosage adjusted accordingly, particularly following initiation, change of dosage, or discontinuation of topiramate therapy.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: warfarin
Brand name: Coumadin, Jantoven
Synonyms: Coumadin
Generic Name: topiramate
Brand name: Qudexy XR Sprinkle, Topamax, Topamax Sprinkle, Trokendi XR, Topiragen, Qudexy XR
Synonyms: Topiramate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Coumadin Injection-Topiramate Extended-Release Sprinkle Capsules
- Coumadin Injection-Topiramate Sprinkle Capsules
- Coumadin Injection-Topiramate Tablets
- Coumadin Injection-Topisulf Cream
- Coumadin Injection-Toposar
- Coumadin Injection-Toposar injection
- Topiramate Extended-Release Capsules-Covaryx
- Topiramate Extended-Release Capsules-Covaryx HS
- Topiramate Extended-Release Capsules-Covera-HS
- Topiramate Extended-Release Capsules-Cozaar
- Topiramate Extended-Release Capsules-CPB WC
- Topiramate Extended-Release Capsules-CPM-PSE DM Drops