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Cytarabine (Conventional) and Flucytosine

Determining the interaction of Cytarabine (Conventional) and Flucytosine and the possibility of their joint administration.

Check result:

Cytarabine (Conventional) <> Flucytosine

Relevance: 19.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Cytarabine may antagonize the antifungal activity of flucytosine by competitive inhibition. The clinical significance is unknown. Data have been conflicting.

References

"Product Information. Ancobon (flucytosine)." Roche Laboratories, Nutley, NJ.
Wingfield HJ "Absence of fungistatic antagonism between flucytosine and cytarabine in vitro and in vivo." J Antimicrob Chemother 20 (1987): 523-7

Cytarabine (Conventional)

Generic Name: cytarabine

Brand name: Cytosar-U, Tarabine PFS, Cytosar

Synonyms: Cytarabine

What is Cytarabine (Conventional)?

Flucytosine

Generic Name: flucytosine

Brand name: Ancobon

Synonyms: n.a.

What is Flucytosine?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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