Dehydrated Alcohol and Diroximel Fumarate
Determining the interaction of Dehydrated Alcohol and Diroximel Fumarate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration of diroximel fumarate with ethanol may reduce the plasma concentrations of monomethyl fumarate (MMF), the active metabolite of diroximel fumarate. The mechanism has not been reported. Following coadministration with 240 mL of 5% v/v and 40% v/v ethanol, the mean peak plasma concentration (Cmax) of MMF was reduced by 9% and 21%, respectively. MANAGEMENT: The manufacturer recommends avoiding concomitant use of diroximel fumarate with ethanol. References "Product Information. Vumerity (diroximel fumarate)." Alkermes, Inc, Cambridge, MA.
Professional:GENERALLY AVOID: Coadministration of diroximel fumarate with ethanol may reduce the plasma concentrations of monomethyl fumarate (MMF), the active metabolite of diroximel fumarate. The mechanism has not been reported. Following coadministration with 240 mL of 5% v/v and 40% v/v ethanol, the mean peak plasma concentration (Cmax) of MMF was reduced by 9% and 21%, respectively.
MANAGEMENT: The manufacturer recommends avoiding concomitant use of diroximel fumarate with ethanol.
- "Product Information. Vumerity (diroximel fumarate)." Alkermes, Inc, Cambridge, MA.
Generic Name: ethanol
Brand name: Ablysinol
Synonyms: n.a.
Generic Name: diroximel fumarate
Brand name:
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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