Dexamethasone Oral Drops and Nilotinib
Determining the interaction of Dexamethasone Oral Drops and Nilotinib and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Dexamethasone may significantly reduce the blood levels of nilotinib, which may make the medication less effective in treating your cancer. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of nilotinib, which is primarily metabolized by the isoenzyme. In healthy subjects receiving the potent inducer rifampin (600 mg once daily for 12 days), nilotinib systemic exposure (AUC) was decreased approximately 80%. Data are not available for nilotinib in combination with other, less potent CYP450 3A4 inducers.
MANAGEMENT: Concomitant use of nilotinib with potent CYP450 3A4 inducers should generally be avoided due to the potential for reduced efficacy. If coadministration is required, a dosage increase for nilotinib may be necessary depending on patient tolerability. The dosage should be reduced to the indicated dosage following discontinuation of the potent CYP450 3A4 inducer.
- "Product Information. Tasigna (nilotinib)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: dexamethasone
Brand name: Baycadron, Decadron, Dexamethasone Intensol, DexPak, TaperDex, Zema-Pak, ZoDex, Zonacort, DexPak 10 Day Taperpak, DexPak 13 DayTaperpak, DexPak 6 DayTaperpak, De-Sone LA, Dexacen-4, Dexasone, Dexasone LA, Solurex, Solurex LA
Synonyms: Dexamethasone, Dexamethasone (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Dexamethasone Oral Drops-Nilstat Drops
- Dexamethasone Oral Drops-Nilstat Powder
- Dexamethasone Oral Drops-Nilutamide
- Dexamethasone Oral Drops-Nimbex
- Dexamethasone Oral Drops-Nimodipine
- Dexamethasone Oral Drops-Nimodipine Capsules
- Nilotinib-Dexamethasone SodiumPhosphate
- Nilotinib-Dexamethasone Solution (Drops)
- Nilotinib-Dexamethasone Tablets
- Nilotinib-Dexamethasone, neomycin, and polymyxin B ophthalmic
- Nilotinib-Dexasone injection
- Nilotinib-Dexasone LA injection