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Disopyramide Capsules and Jantoven

Determining the interaction of Disopyramide Capsules and Jantoven and the possibility of their joint administration.

Check result:
Disopyramide Capsules <> Jantoven
Relevance: 11.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited data suggest that the anticoagulant effects of warfarin and dicumarol may be enhanced by disopyramide and decreased upon its withdrawal. The mechanism is unknown. The data are conflicting, and the impact of improved hemodynamic status on the anticoagulant effect has not been controlled for. Although no special precautions appear to be necessary, it is recommended that the PT or INR be followed when disopyramide is added or discontinued.

References
  • Haworth E, Burroughs AK "Disopyramide and warfarin interaction." Br Med J 2 (1977): 866-7
  • Ryll C, Davis LJ "Warfarin-disopyramide interaction?" Drug Intell Clin Pharm 13 (1979): 260
  • Sylven C, Anderson P "Evidence that disopyramide does not interact with warfarin." Br Med J 286 (1983): 1181
Disopyramide Capsules

Generic Name: disopyramide

Brand name: Norpace, Norpace CR

Synonyms: Disopyramide

Jantoven

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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