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Disulfiram and Phenytek

Determining the interaction of Disulfiram and Phenytek and the possibility of their joint administration.

Check result:

Disulfiram <> Phenytek

Relevance: 08.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using phenytoin together with disulfiram may increase the effects of phenytoin. Contact your doctor if you experience twitching eye movements, slurred speech, loss of balance, tremor, muscle stiffness or weakness, nausea, vomiting, feeling light-headed, fainting, and slow or shallow breathing. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Phenytoin serum levels may increase significantly in the presence of disulfiram. Rapid increases in serum phenytoin levels of 73% to 500% have been reported. Disulfiram may inhibit hepatic microsomal metabolism of phenytoin and decrease its elimination rate. Theoretically, other hydantoins may be similarly affected.

MANAGEMENT: Patients should be closely observed for signs of hydantoin toxicity if these drugs must be given concurrently and serum phenytoin concentrations should be monitored. Patients should be advised to notify their physician if they experience symptoms of toxicity, including drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia. The hydantoin dose may need to be decreased. In addition, the dose of the hydantoin may require adjustment when initiating or discontinuing treatment with disulfiram. Recovery may take two to three weeks after treatment with disulfiram is discontinued.

References

Taylor JW, Alexander B, Lyon LW "Mathematical analysis of a phenytoin-disulfiram interaction." Am J Hosp Pharm 38 (1981): 93-5
Kiorboe E "Phenytoin intoxication during treatment with antabuse (disulfiram)." Epilepsia 7 (1966): 246-9
Brown CG, Kaminsky MJ, Feroli ER, Gurley HT "Delirium with phenytoin and disulfiram administration." Ann Emerg Med 12 (1983): 310-3
Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Olesen OV "Disulfiram (antabuse) as inhibitor of phenytoin metabolism." Acta Pharmacol Toxicol (Copenh) 24 (1966): 317-22

Disulfiram

Generic Name: disulfiram

Brand name: Antabuse

Synonyms: n.a.

What is Disulfiram?

Phenytek

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: n.a.

What is Phenytek?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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