Dronedarone Hydrochloride and Luvox

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

FluvoxaMINE may increase the blood levels and effects of dronedarone. High blood levels of dronedarone can cause an irregular heart rhythm that may be serious. Your doctor may want you to have ECGs performed regularly while you are on dronedarone. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, chest pain, difficulty breathing, shortness of breath, or an irregular heartbeat (too fast or too slow). It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of dronedarone, which is primarily metabolized by the isoenzyme. According to the product labeling for dronedarone, administration of repeated doses of the potent inhibitor ketoconazole led to a 9-fold increase in dronedarone peak plasma concentration (Cmax) and a 17-fold increase in systemic exposure (AUC). Because dronedarone is associated with concentration-dependent prolongation of the QT interval, increased levels may potentiate the risk of ventricular arrhythmias such as torsade de pointes and sudden death. Data are not available for dronedarone in combination with other, less potent CYP450 3A4 inhibitors.

MANAGEMENT: Caution is advised if dronedarone is prescribed in combination with CYP450 3A4 inhibitors. Pharmacologic response to dronedarone should be monitored more closely whenever a CYP450 3A4 inhibitor is added to or withdrawn from therapy. Patients should be advised to seek medical attention if they experience symptoms that could indicate dronedarone toxicity such as excessive fatigue, fainting, difficulty breathing, chest pain or tightness, bradycardia, or symptoms of torsade de pointes such as dizziness, palpitations, and syncope. Dronedarone should be discontinued if QTc Bazett interval increases to 500 ms or greater.

Dronedarone Hydrochloride

Generic Name: dronedarone

Brand name: Multaq

Synonyms: Dronedarone

What is Dronedarone Hydrochloride?

Luvox

Generic Name: fluvoxamine

Brand name: Luvox, Luvox CR

Synonyms: n.a.

What is Luvox?