Edoxaban Tosylate and Fosphenytoin Sodium
Determining the interaction of Edoxaban Tosylate and Fosphenytoin Sodium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Fosphenytoin may reduce the blood levels of edoxaban, which may make the medication less effective in preventing blood clots. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of P-glycoprotein (P-gp) may reduce the bioavailability of edoxaban, which is a substrate of the efflux transporter. According to the product labeling, the potent P-gp inducer rifampin decreased single-dose edoxaban systemic exposure (AUC) by approximately 35%.
MANAGEMENT: Caution is advised if edoxaban is used with P-gp inducers. Pharmacologic response to edoxaban should be monitored more closely whenever a P-gp inducer is added to or withdrawn from therapy, and the edoxaban dosage adjusted as necessary.
- Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
- "Product Information. Savaysa (edoxaban)." Daiichi Sankyo, Inc., Parsippany, NJ.
Generic Name: edoxaban
Brand name: Savaysa
Synonyms: Edoxaban
Generic Name: fosphenytoin
Brand name: Cerebyx
Synonyms: Fosphenytoin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Edoxaban Tosylate-Fospropofol Intravenous
- Edoxaban Tosylate-Fosrenol
- Edoxaban Tosylate-Fosrenol (Lanthanum Chewable Tablets)
- Edoxaban Tosylate-Fosrenol (Lanthanum Powder)
- Edoxaban Tosylate-Fostamatinib
- Edoxaban Tosylate-Fostamatinib disodium
- Fosphenytoin Sodium-Edrophonium and Atropine
- Fosphenytoin Sodium-Edrophonium Injection
- Fosphenytoin Sodium-Edurant
- Fosphenytoin Sodium-EEMT
- Fosphenytoin Sodium-EEMT DS
- Fosphenytoin Sodium-EEMT HS