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Ethotoin and Pentamycetin Ophthalmic Solution 0.25%

Determining the interaction of Ethotoin and Pentamycetin Ophthalmic Solution 0.25% and the possibility of their joint administration.

Check result:

Ethotoin <> Pentamycetin Ophthalmic Solution 0.25%

Relevance: 28.12.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using chloramphenicol ophthalmic together with ethotoin. Using chloramphenicol ophthalmic with ethotoin can increase the effects of ethotoin. Symptoms of a ethotoin toxicity may include twitching eye movements, slurred speech, drowsiness, loss of balance, tremor, muscle stiffness or weakness, nausea, vomiting, feeling light-headed, fainting, and slow or shallow breathing. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Chloramphenicol often markedly increases serum phenytoin levels. Toxicity has been reported. The mechanism is inhibition of CYP450 metabolism of phenytoin. Phenytoin has also been reported both to increase and to decrease serum chloramphenicol levels by an unknown mechanism. Ethotoin theoretically may behave in a similar fashion. It is not expected that systemic absorption will occur with otic or ophthalmic chloramphenicol. The clinician should, however, be aware of the possibility.

MANAGEMENT: This combination should usually be avoided if possible. If patients do receive these agents concomitantly, serum concentrations should be closely monitored. Patients should be advised to notify their physician if they experience symptoms of hydantoin toxicity, including drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia.

References

Saltiel M, Stephens NM "Phenytoin-chloramphenicol interaction." Drug Intell Clin Pharm 14 (1980): 221
Harper JM, Yost RL, Stewart RB, Ciezkowski J "Phenytoin-chloramphenicol interaction: a retrospective study." Drug Intell Clin Pharm 13 (1979): 425-9
Krasinski K, Kusmiesz H, Nelson JD "Pharmacologic interactions among chloramphenicol, phenytoin and phenobarbital." Pediatr Infect Dis 1 (1982): 232-5
Christensen LK, Skovsted L "Inhibition of drug metabolism by chloramphenicol." Lancet 2 (1969): 1397-9
Rose JQ, Choi HK, Schentag JJ, et al "Intoxication caused by interaction of chloramphenicol and phenytoin." JAMA 237 (1977): 2630-1
Powell DA, Nahata MC, Durrell DC, et al "Interactions among chloramphenicol, phenytoin, and phenobarbital in a pediatric patient." J Pediatr 98 (1981): 1001-3

Ethotoin

Generic Name: ethotoin

Brand name: Peganone

Synonyms: n.a.

What is Ethotoin?

Pentamycetin Ophthalmic Solution 0.25%

Generic Name: chloramphenicol ophthalmic

Brand name:

Synonyms: Chloramphenicol (Ophthalmic)

What is Pentamycetin Ophthalmic Solution 0.25%?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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