Ezetimibe and Flax

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.MONITOR: Concomitant use of flaxseed oil with ezetimibe may lead to lower plasma alpha-linolenic acid (ALA) levels. The mechanism may be related to ezetimibe-mediated inhibition of intestinal absorption of ALA contained in flaxseed oil. However, data for this interaction are conflicting. In one study, 34 cardiac disease patients were randomized into 4 groups for a 6-week trial of a daily dose of either: placebo, 10 mg ezetimibe, 2 g flaxseed oil (equivalent to 1 g ALA), or 10 mg ezetimibe with 2 g flaxseed oil. The flaxseed oil group presented a significant increase in ALA plasma levels of 6 mcg/dL, and the other groups showed a decrease in ALA plasma levels of 2 to 4 mcg/dL as compared to baseline. However, according to ezetimibe product labeling, preclinical studies showed no effects of ezetimibe on fatty acid absorption. MANAGEMENT: Until further information is available, clinical or laboratory monitoring of the expected therapeutic benefits of flaxseed oil is recommended when ezetimibe is co-administered with flaxseed oil. References Cerner Multum, Inc. "Australian Product Information." O 0 "Product Information. Zetia (ezetimibe)." Schering-Plough Corporation, Kenilworth, NJ. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

MONITOR: Concomitant use of flaxseed oil with ezetimibe may lead to lower plasma alpha-linolenic acid (ALA) levels. The mechanism may be related to ezetimibe-mediated inhibition of intestinal absorption of ALA contained in flaxseed oil. However, data for this interaction are conflicting. In one study, 34 cardiac disease patients were randomized into 4 groups for a 6-week trial of a daily dose of either: placebo, 10 mg ezetimibe, 2 g flaxseed oil (equivalent to 1 g ALA), or 10 mg ezetimibe with 2 g flaxseed oil. The flaxseed oil group presented a significant increase in ALA plasma levels of 6 mcg/dL, and the other groups showed a decrease in ALA plasma levels of 2 to 4 mcg/dL as compared to baseline. However, according to ezetimibe product labeling, preclinical studies showed no effects of ezetimibe on fatty acid absorption.

MANAGEMENT: Until further information is available, clinical or laboratory monitoring of the expected therapeutic benefits of flaxseed oil is recommended when ezetimibe is co-administered with flaxseed oil.

Ezetimibe

Generic Name: ezetimibe

Brand name: Zetia

Synonyms: n.a.

What is Ezetimibe?

Flax

Generic Name: flax

Brand name: Flax Seed Oil, Flax Oil

Synonyms: n.a.

What is Flax?