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FluMist Quadrivalent 2015-2016 Formula and Mayzent

Determining the interaction of FluMist Quadrivalent 2015-2016 Formula and Mayzent and the possibility of their joint administration.

Check result:
FluMist Quadrivalent 2015-2016 Formula <> Mayzent
Relevance: 02.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.GENERALLY AVOID: The administration of live, attenuated viral or bacterial vaccines during siponimod therapy may be associated with a risk of disseminated infection due to enhanced replication of vaccine virus or bacteria in the presence of diminished immune competence. Siponimod causes reversible sequestration of lymphocytes in lymphoid tissues. A dose-dependent reduction in peripheral lymphocyte count to 20% to 30% of baseline values has been observed, which may increase the risk of infections. Vaccination may also be less effective during and for up to one month after discontinuation of siponimod therapy. MANAGEMENT: The use of live attenuated vaccines should be avoided during and for up to 4 weeks after siponimod treatment, and siponimod should be paused 1 week prior to and until 4 weeks after a planned vaccination. Patients without a healthcare professional confirmed history of varicella or without documentation of a full course of vaccination against varicella-zoster virus (VZV) should be tested for antibodies to VZV before initiating treatment with siponimod. For antibody-negative patients, a full course of vaccination with varicella vaccine is recommended prior to treatment with siponimod. In patients who have recently been vaccinated, siponimod therapy should be postponed for 4 weeks to allow the full effect of vaccination to occur. References "Product Information. Mayzent (siponimod)." Novartis Pharmaceuticals, East Hanover, NJ.

Professional:

GENERALLY AVOID: The administration of live, attenuated viral or bacterial vaccines during siponimod therapy may be associated with a risk of disseminated infection due to enhanced replication of vaccine virus or bacteria in the presence of diminished immune competence. Siponimod causes reversible sequestration of lymphocytes in lymphoid tissues. A dose-dependent reduction in peripheral lymphocyte count to 20% to 30% of baseline values has been observed, which may increase the risk of infections. Vaccination may also be less effective during and for up to one month after discontinuation of siponimod therapy.

MANAGEMENT: The use of live attenuated vaccines should be avoided during and for up to 4 weeks after siponimod treatment, and siponimod should be paused 1 week prior to and until 4 weeks after a planned vaccination. Patients without a healthcare professional confirmed history of varicella or without documentation of a full course of vaccination against varicella-zoster virus (VZV) should be tested for antibodies to VZV before initiating treatment with siponimod. For antibody-negative patients, a full course of vaccination with varicella vaccine is recommended prior to treatment with siponimod. In patients who have recently been vaccinated, siponimod therapy should be postponed for 4 weeks to allow the full effect of vaccination to occur.

References
  • "Product Information. Mayzent (siponimod)." Novartis Pharmaceuticals, East Hanover, NJ.
FluMist Quadrivalent 2015-2016 Formula

Generic Name: influenza virus vaccine, live, trivalent

Brand name: FluMist 2018-2019, Flumist, FluMist 2010-2011, FluMist 2011-2012, FluMist 2012-2013, FluMist 2013-2014, FluMist 2014-2015, FluMist 2015-2016, FluMist 2016-2017, FluMist Quadrivalent 2019-2020, FluMist Quadrivalent

Synonyms: Influenza virus vaccine (nasal), Influenza Virus Vaccine (Live/Attenuated)

Mayzent

Generic Name: siponimod

Brand name: Mayzent, Mayzent Starter Pack

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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