Fortovase and Nefazodone

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using nefazodone together with saquinavir may increase the blood levels and effects of saquinavir. Nefazodone can increase the blood levels of saquinavir to dangerous levels and cause an irregular heart rhythm that may be serious. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats during treatment with nefazodone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with nefazodone may increase the plasma concentrations and the risk of adverse effects of saquinavir. The proposed mechanism is decreased clearance due to nefazodone-mediated inhibition of CYP450 3A4 metabolism.

MANAGEMENT: Caution is advised if nefazodone is used in combination with saquinavir. Clinical and laboratory monitoring should be considered whenever nefazodone is added to or withdrawn from therapy. Patients should be monitored for the development of saquinavir toxicity including cardiac arrhythmias.

Fortovase

Generic Name: saquinavir

Brand name: Invirase, Fortovase

Synonyms: n.a.

What is Fortovase?

Nefazodone

Generic Name: nefazodone

Brand name: Serzone

Synonyms: n.a.

What is Nefazodone?