Fosphenytoin and Hyperstat

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using fosphenytoin together with diazoxide may alter the effects of both medications. Contact your doctor if your condition changes or if you experience loss of seizure control. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Phenytoin may significantly decrease the effects of diazoxide and that diazoxide may significantly decrease the effects of phenytoin. The proposed mechanism is induction of phenytoin metabolism and clearance by diazoxide. Phenytoin reduces the half-life of diazoxide. Loss of seizure control has occurred.

MANAGEMENT: Caution and close observation are recommended if these drugs must be used together. Patients should be monitored for seizure activity and altered diazoxide effects (e.g., hypoglycemia).

Fosphenytoin

Generic Name: fosphenytoin

Brand name: Cerebyx

Synonyms: n.a.

What is Fosphenytoin?

Hyperstat

Generic Name: diazoxide

Brand name: Proglycem, Hyperstat

Synonyms: n.a.

What is Hyperstat?