Fosphenytoin and Polatuzumab vedotin
Determining the interaction of Fosphenytoin and Polatuzumab vedotin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may decrease exposure to unconjugated monomethyl auristatin E (MMAE), the anti-mitotic and cytotoxic component of polatuzumab vedotin. MMAE is a substrate for CYP450 3A4. Concomitant use of polatuzumab vedotin with rifampin, a potent CYP450 3A4 inducer, is predicted to decrease unconjugated MMAE exposure (AUC) by 63% according to the product labeling. MANAGEMENT: Concomitant use of polatuzumab vedotin with potent CYP450 3A4 inducers should be avoided, if possible, due to the potential for reduced efficacy. References "Product Information. Polivy (polatuzumab vedotin)." Genentech, South San Francisco, CA.
Professional:GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may decrease exposure to unconjugated monomethyl auristatin E (MMAE), the anti-mitotic and cytotoxic component of polatuzumab vedotin. MMAE is a substrate for CYP450 3A4. Concomitant use of polatuzumab vedotin with rifampin, a potent CYP450 3A4 inducer, is predicted to decrease unconjugated MMAE exposure (AUC) by 63% according to the product labeling.
MANAGEMENT: Concomitant use of polatuzumab vedotin with potent CYP450 3A4 inducers should be avoided, if possible, due to the potential for reduced efficacy.
- "Product Information. Polivy (polatuzumab vedotin)." Genentech, South San Francisco, CA.
Generic Name: polatuzumab vedotin
Brand name: Polivy
Synonyms: Polatuzumab Vedotin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Polatuzumab vedotin-Fosphenytoin Injection
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- Polatuzumab vedotin-Fosrenol
- Polatuzumab vedotin-Fosrenol (Lanthanum Chewable Tablets)
- Polatuzumab vedotin-Fosrenol (Lanthanum Powder)