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Fosphenytoin and Retrovir (Zidovudine Syrup)

Determining the interaction of Fosphenytoin and Retrovir (Zidovudine Syrup) and the possibility of their joint administration.

Check result:
Fosphenytoin <> Retrovir (Zidovudine Syrup)
Relevance: 21.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

One study has suggested that zidovudine may have variable effects on plasma phenytoin levels. Increased levels, decreased levels, and no change have been reported. If zidovudine and phenytoin must be used together, close observation for altered clinical and laboratory effects is recommended.

References
  • Burger DM, Meenhorst PL, Koks CH, Beijnen JH "Phenytoin (PH) monitoring in HIV(+) individuals: is there an interaction with zidovudine (ZDV)?" Int Conf AIDS 9 (1993): 504
Fosphenytoin

Generic Name: fosphenytoin

Brand name: Cerebyx

Synonyms: n.a.

Retrovir (Zidovudine Syrup)

Generic Name: zidovudine

Brand name: Retrovir

Synonyms: Retrovir (oral/injection), Retrovir

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle