Fosphenytoin Injection and Pentobarbital Sodium Injection
Determining the interaction of Fosphenytoin Injection and Pentobarbital Sodium Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using fosphenytoin together with PENTobarbital may affect your seizure control. You may need dose adjustments or special tests in order to safely take both medications together. This combination may alter fosphenytoin levels. You should notify your doctor if you have a loss of seizure control or possible symptoms such as nausea, vomiting, tremors, loss of muscle coordination, lethargy, slurred speech, visual disturbances, or changes in mental status. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Barbiturates may induce or inhibit the metabolism of phenytoin. Plasma phenytoin concentrations may be decreased or increased. The mechanism are induction of hepatic CYP450 phenytoin metabolism by therapeutic doses of barbiturates, and competitive inhibition of metabolism by large doses. Also, when phenytoin is added to a regimen, the plasma levels of barbiturates may significantly increase via an unknown mechanism.
MANAGEMENT: Close laboratory and clinical observation for altered effects of both agents is recommended when doses of either agent are started, changed, or discontinued. Patients should be advised to notify their physician if they experience loss of seizure control or excessive or prolonged sedative effects. It may be necessary to alter the dosage of one or both of the drugs.
- Kuranari M, Tatsukawa H, Seike M, et al. "Effect of phenytoin on phenobarbital pharmacokinetics in a patient with epilepsy." Ann Pharmacother 29 (1995): 83-4
- Yoshida N, Oda Y, Nishi S, Abe J, Kaji A, Asada A, Fujimori M "Effect of barbiturate therapy on phenytoin pharmacokinetics." Crit Care Med 21 (1993): 1514-22
Generic Name: fosphenytoin
Brand name: Cerebyx
Synonyms: Fosphenytoin
Generic Name: pentobarbital
Brand name: Nembutal Sodium, Nembutal
Synonyms: Pentobarbital (injection), PENTobarbital
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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