Fosphenytoin Injection and Trimethoprim Oral Solution
Determining the interaction of Fosphenytoin Injection and Trimethoprim Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using fosphenytoin together with trimethoprim may increase the effects of fosphenytoin. Contact your doctor if you experience twitching eye movements, slurred speech, loss of balance, tremor, muscle stiffness or weakness, nausea, vomiting, feeling light-headed, fainting, and slow or shallow breathing. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Trimethoprim may inhibit the CYP450 hepatic metabolism of hydantoins. Serum hydantoin levels and risk of toxicity may be increased. Data are available for phenytoin.
MANAGEMENT: Monitoring for clinical and laboratory evidence of hydantoin toxicity is recommended. Dose adjustments may be necessary. Patients should be advised to notify their physician if they experience symptoms of hydantoin toxicity (e.g., drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia).
- Gillman MA "Phenytoin toxicity and co-trimazole." Ann Intern Med 102 (1985): 559
- Hansen JM, Kampmann JP, Siersback-Nielsen K, et al. "The effect of different sulfonamides on phenytoin metabolism in man." Acta Med Scand Suppl 624 (1979): 106-10
Generic Name: fosphenytoin
Brand name: Cerebyx
Synonyms: Fosphenytoin
Generic Name: trimethoprim
Brand name: Primsol, Trimpex, Proloprim
Synonyms: Trimethoprim
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Fosphenytoin Injection-Trimethoprim Tablets
- Fosphenytoin Injection-Trimipramine
- Fosphenytoin Injection-Trimipramine Capsules
- Fosphenytoin Injection-Trimipramine Maleate
- Fosphenytoin Injection-Trimo San Jelly
- Fosphenytoin Injection-Trimo-San vaginal
- Trimethoprim Oral Solution-Fosphenytoin Sodium
- Trimethoprim Oral Solution-Fospropofol Intravenous
- Trimethoprim Oral Solution-Fosrenol
- Trimethoprim Oral Solution-Fosrenol (Lanthanum Chewable Tablets)
- Trimethoprim Oral Solution-Fosrenol (Lanthanum Powder)
- Trimethoprim Oral Solution-Fostamatinib