Glyburide and Turalio

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.MONITOR: Coadministration with pexidartinib may increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of multidrug and toxin extrusion protein 1 (MATE1) and 2K (MATE2K) and organic anion transporting polypeptide (OATP) 1B1, 1B3, and 2B1. The proposed mechanism, based on in vitro data, is decreased clearance due to pexidartinib-mediated inhibition of these transport proteins. MANAGEMENT: Caution is advised if pexidartinib is used concomitantly with drugs that are substrates of MATE1, MATE2K, OATP1B1, OATP1B3, and OATP2B1, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever pexidartinib is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects. References "Product Information. Turalio (pexidartinib)." Daiichi Sankyo, Inc., Parsippany, NJ.

MONITOR: Coadministration with pexidartinib may increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of multidrug and toxin extrusion protein 1 (MATE1) and 2K (MATE2K) and organic anion transporting polypeptide (OATP) 1B1, 1B3, and 2B1. The proposed mechanism, based on in vitro data, is decreased clearance due to pexidartinib-mediated inhibition of these transport proteins.

MANAGEMENT: Caution is advised if pexidartinib is used concomitantly with drugs that are substrates of MATE1, MATE2K, OATP1B1, OATP1B3, and OATP2B1, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever pexidartinib is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects.

Glyburide

Generic Name: glyburide

Brand name: DiaBeta, Glynase PresTab, Micronase, DiaBeta, Glynase

Synonyms: GlyBURIDE

What is Glyburide?

Turalio

Generic Name: pexidartinib

Brand name: Turalio

Synonyms: n.a.

What is Turalio?