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Halothane and Phenytek

Determining the interaction of Halothane and Phenytek and the possibility of their joint administration.

Check result:
Halothane <> Phenytek
Relevance: 08.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

A case has been reported of phenytoin intoxication following halothane anesthesia. The authors have suggested that temporary hepatic function was the cause of the acute phenytoin intoxication. If phenytoin and halothane are to be use to coadministered, clinical and laboratory signs of altered phenytoin levels should be monitored.

References
  • Karlin JM, Kutt H "Acute diphenylhydantoin intoxication following halothane anesthesia." J Pediatr 76 (1970): 941-4
Halothane

Generic Name: halothane

Brand name:

Synonyms: n.a.

Phenytek

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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