Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir and Olaparib
Determining the interaction of Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir and Olaparib and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:PHENobarbital may significantly reduce the blood levels of olaparib, which may make the medication less effective in treating your cancer. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with potent and moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of olaparib, which is primarily metabolized by the isoenzyme. In a drug interaction study with 22 patients, olaparib peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by approximately 71% and 87%, respectively, during coadministration with the potent CYP450 3A4 inducer rifampin. Simulations using physiologically-based pharmacokinetic (PBPK) models suggest that a moderate inducer (efavirenz) may decrease olaparib Cmax by 20% to 30% and AUC by 50% to 60%.
MANAGEMENT: Concomitant use of olaparib with potent and moderate CYP450 3A4 inducers should generally be avoided. If coadministration with a moderate CYP450 3A4 inducer such as bosentan, dexamethasone, efavirenz, etravirine, modafinil or nafcillin is required, the potential for decreased efficacy of olaparib should be considered.
- "Product Information. Lynparza (olaparib)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: atropine / hyoscyamine / phenobarbital / scopolamine
Brand name: Donnatal, D-Tal, Phenohytro, Chardonna-2, Hyosophen, Donnapine, Elixiral, Bellatal, Spasmolin, Haponal, Antispas, Barbidonna, Donnatal Extentabs, Antispasmodic, Bellalphen, Donnaphen, Spasquid, Alkabel-SR, Bellatal ER, Servira, PB-Hyos, Quadrapax, Phenobarbital with Belladonna Alkaloids
Synonyms: Belladonna alkaloids and phenobarbital, Hyoscyamine, Atropine, Scopolamine, and Phenobarbital
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir-Olaparib Capsules
- Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir-Olaparib Tablets
- Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir-Olaratumab
- Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir-Olaratumab Intravenous
- Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir-Oleptro
- Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir-Oleptro Oral
- Olaparib-Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Tablets
- Olaparib-Hyoscyamine, methenamine, methylene blue, and sodium biphosphate
- Olaparib-Hyoscyamine, Methenamine, Methylene Blue, and Sodium Phosphate Monobasic
- Olaparib-Hyoscyamine, methenamine, methylene blue, phenyl salicylate, and sodium phosphate
- Olaparib-Hyoscyamine, methenamine, methylene blue, phenyl salicylate, sodium biphosphate
- Olaparib-Hyosophen