Ivosidenib and Nifedipine Extended-Release Tablets
Determining the interaction of Ivosidenib and Nifedipine Extended-Release Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration with ivosidenib may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. No pharmacokinetic data are available; however, ivosidenib induces its own metabolism via CYP450 3A4. MANAGEMENT: Concomitant use of ivosidenib and sensitive CYP450 3A4 substrates or substrates with narrow therapeutic ranges should generally be avoided. If coadministration is required, patients should be monitored carefully for potential loss of therapeutic effects. References "Product Information. Tibsovo (ivosidenib)." Agios Pharmaceuticals, Cambridge, MA.
Professional:GENERALLY AVOID: Coadministration with ivosidenib may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. No pharmacokinetic data are available; however, ivosidenib induces its own metabolism via CYP450 3A4.
MANAGEMENT: Concomitant use of ivosidenib and sensitive CYP450 3A4 substrates or substrates with narrow therapeutic ranges should generally be avoided. If coadministration is required, patients should be monitored carefully for potential loss of therapeutic effects.
- "Product Information. Tibsovo (ivosidenib)." Agios Pharmaceuticals, Cambridge, MA.
Generic Name: nifedipine
Brand name: Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia, Procardia XL, Adalat
Synonyms: Nifedipine, NIFEdipine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ivosidenib-Niferex
- Ivosidenib-Niferex Elixir
- Ivosidenib-Night Cast R Topical
- Ivosidenib-Night Cast S Topical
- Ivosidenib-Night Time Cold/Flu
- Ivosidenib-Night Time Pain
- Nifedipine Extended-Release Tablets-Ivy Soothe
- Nifedipine Extended-Release Tablets-IvyStat
- Nifedipine Extended-Release Tablets-Ixabepilone
- Nifedipine Extended-Release Tablets-Ixabepilone Intravenous
- Nifedipine Extended-Release Tablets-Ixazomib
- Nifedipine Extended-Release Tablets-Ixazomib Citrate