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Kondremul and Phytonadione

Determining the interaction of Kondremul and Phytonadione and the possibility of their joint administration.

Check result:
Kondremul <> Phytonadione
Relevance: 28.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration of mineral oil and oral vitamin K (a fat soluble vitamin) may lead to decreased effectiveness of vitamin K. Mineral oil most likely decreases gastrointestinal absorption of vitamin K. Consider either separating the doses by at least 3 hours, substituting mineral oil with alternative therapy or using parenteral vitamin K.

References
  • "Product Information. Mephyton (phytonadione)." Merck & Co, Inc, West Point, PA.
Kondremul

Generic Name: mineral oil

Brand name: Kondremul, Fleet Mineral Oil Enema, Kondremul Plain, Muri-Lube, Milkinol, Mineral Oil, Light, Heavy, Liqui Doss, Leader Mineral Oil Enema

Synonyms: n.a.

Phytonadione

Generic Name: phytonadione

Brand name: Aquamephyton, Konakion, Mephyton, Vitamin K1

Synonyms: Phytonadione (oral/injection)

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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