Lamivudine and Zidovudine Tablets and Midazolam Hydrochloride
Determining the interaction of Lamivudine and Zidovudine Tablets and Midazolam Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:One study has suggested that patients receiving zidovudine and a benzodiazepine concomitantly may demonstrate increased plasma clearance of the benzodiazepine. That study also has suggested that patients on concomitant therapy may experience an increased number of headaches. Oxazepam was the only benzodiazepine specifically implicated. However, other benzodiazepines also may participate in this interaction.
- Mole L, Israelski D, Bubp J, O'Hanley P, Merigan T, Blaschke T "Pharmacokinetics of zidovudine alone and in combination with oxazepam in the HIV infected patient." J Acquir Immune Defic Syndr 6 (1993): 56-60
Generic Name: lamivudine / zidovudine
Brand name: Combivir
Synonyms: Lamivudine and zidovudine, Lamivudine and Zidovudine
Generic Name: midazolam
Brand name: Versed, Nayzilam
Synonyms: Midazolam
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Lamivudine and Zidovudine Tablets-Midazolam injection
- Lamivudine and Zidovudine Tablets-Midazolam Injection Hospira
- Lamivudine and Zidovudine Tablets-Midazolam nasal
- Lamivudine and Zidovudine Tablets-Midazolam Nasal Spray
- Lamivudine and Zidovudine Tablets-Midazolam Syrup
- Lamivudine and Zidovudine Tablets-Midodrine
- Midazolam Hydrochloride-Lamivudine Oral Solution
- Midazolam Hydrochloride-Lamivudine Tablets
- Midazolam Hydrochloride-Lamotrigine
- Midazolam Hydrochloride-Lamotrigine Chewable Dispersible Tablets
- Midazolam Hydrochloride-Lamotrigine Chewable Tablet
- Midazolam Hydrochloride-Lamotrigine Extended Release Tablet