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Lanoxin Injection Pediatric and Serzone

Determining the interaction of Lanoxin Injection Pediatric and Serzone and the possibility of their joint administration.

Check result:
Lanoxin Injection Pediatric <> Serzone
Relevance: 07.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using digoxin together with nefazodone may increase the effects of digoxin. Contact your doctor if you experience nausea, vomiting, decreased appetite, diarrhea, confusion, seizures, hallucinations, light "halos" around objects, green or yellow vision, fatigue, irregular heartbeats, and abnormally fast or slow heartbeats. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Nefazodone can increase serum digoxin concentration by almost 30%. The mechanism is unknown.

MANAGEMENT: Patients receiving digoxin should be monitored closely when nefazodone is added to or deleted from the regimen, and the digoxin dosage adjusted accordingly. Patients should be advised to notify their physicians if they experience signs of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeats.

References
  • Dockens RC, Greene DS, Barbhaiya RH "Assessment of pharmacokinetic and pharmacodynamic drug interactions between nefazodone and digoxin in healthy male volunteers." J Clin Pharmacol 36 (1996): 160-7
Lanoxin Injection Pediatric

Generic Name: digoxin

Brand name: Lanoxin, Digitek, Digox, Lanoxicaps, Cardoxin

Synonyms: Lanoxin

Serzone

Generic Name: nefazodone

Brand name: Serzone

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction