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Larotrectinib Oral Solution and Nexavar

Determining the interaction of Larotrectinib Oral Solution and Nexavar and the possibility of their joint administration.

Check result:

Larotrectinib Oral Solution <> Nexavar

Relevance: 06.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.MONITOR: Based on in vitro inhibition data, coadministration with sorafenib may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) transporter. The proposed mechanism is decreased clearance in the intestine, liver, and/or kidney due to inhibition of P-glycoprotein-mediated drug efflux by sorafenib. MANAGEMENT: Caution is advised when sorafenib is used concurrently with drugs that are known P-gp substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever sorafenib is added to or withdrawn from therapy. References "Product Information. Nexavar (sorafenib)." Bayer Pharmaceutical Inc, West Haven, CT. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Professional:

MONITOR: Based on in vitro inhibition data, coadministration with sorafenib may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) transporter. The proposed mechanism is decreased clearance in the intestine, liver, and/or kidney due to inhibition of P-glycoprotein-mediated drug efflux by sorafenib.

MANAGEMENT: Caution is advised when sorafenib is used concurrently with drugs that are known P-gp substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever sorafenib is added to or withdrawn from therapy.

References

"Product Information. Nexavar (sorafenib)." Bayer Pharmaceutical Inc, West Haven, CT.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Larotrectinib Oral Solution

Generic Name: larotrectinib

Brand name: Vitrakvi

Synonyms: Larotrectinib

What is Larotrectinib Oral Solution?

Nexavar

Generic Name: sorafenib

Brand name: Nexavar

Synonyms: n.a.

What is Nexavar?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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