Leuprolide and norethindrone Intramuscular, Oral and Nefazodone Hydrochloride
Determining the interaction of Leuprolide and norethindrone Intramuscular, Oral and Nefazodone Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Nefazodone may increase the blood levels and effects of norethindrone. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with nefazodone may increase the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is decreased clearance due to inhibition of CYP450 3A4 activity by nefazodone.
MANAGEMENT: Caution is advised if nefazodone must be used concomitantly with medications that undergo metabolism by CYP450 3A4, particularly those with a narrow therapeutic range. A lower initial dosage, as well as clinical and laboratory monitoring, may be appropriate for some drugs.
- "Product Information. Serzone (nefazodone)." Bristol-Myers Squibb, Princeton, NJ.
Generic Name: leuprolide / norethindrone
Brand name: Lupaneta Pack
Synonyms: Leuprolide and norethindrone, Leuprolide and Norethindrone
Generic Name: nefazodone
Brand name: Serzone
Synonyms: Nefazodone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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