Levothyroxine Oral Solution and Propranolol Injection
Determining the interaction of Levothyroxine Oral Solution and Propranolol Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Thyroid hormone therapy may reverse decreased hepatic blood flow associated with hypothyroidism. Increased hepatic metabolism and decreased serum levels of some beta-blockers may result. Data are available for propranolol only. No special precautions are necessary. When hypothyroidism is converted to a euthyroid state, a decrease in beta-blocking effectiveness is possible.
- Aro A, Antila M, Korhonen T, Sundquist H "Pharmacokinetics of propranolol and sotalol in hyperthyroidism." Eur J Clin Pharmacol 21 (1982): 373-7
- Wells PG, Feely J, Wilkinson GR, Wood AJ "Effect of thyrotoxicosis on liver blood flow and propranolol disposition after long-term dosing." Clin Pharmacol Ther 33 (1983): 603-8
Generic Name: levothyroxine
Brand name: Levoxyl, Synthroid, Tirosint, Unithroid, Euthyrox, Levothroid, Tirosint-Sol
Synonyms: Levothyroxine
Generic Name: propranolol
Brand name: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal, InnoPran XL
Synonyms: Propranolol
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Levothyroxine Oral Solution-Propranolol Intravenous
- Levothyroxine Oral Solution-Propranolol Oral Solution
- Levothyroxine Oral Solution-Propranolol Oral Solution (Hemangeol)
- Levothyroxine Oral Solution-Propranolol Sustained-Release Bead Capsules
- Levothyroxine Oral Solution-Propranolol Sustained-Release Capsules
- Levothyroxine Oral Solution-Propranolol Tablets
- Propranolol Injection-Levothyroxine oral/injection
- Propranolol Injection-Levothyroxine Sodium
- Propranolol Injection-Levothyroxine Tablets
- Propranolol Injection-Levoxyl
- Propranolol Injection-Levsin
- Propranolol Injection-Levsin (Hyoscyamine Injection)