Liptruzet Tablets and Serzone

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using atorvastatin together with nefazodone. Combining these medications may significantly increase the blood levels of atorvastatin. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. In some cases, rhabdomyolysis can cause kidney damage and even death. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications, or your doctor may prescribe alternative medications that do not interact. Let your doctor know immediately if you have unexplained muscle pain, tenderness, or weakness during treatment with atorvastatin or similar medications, especially if these symptoms are accompanied by fever or dark colored urine. You should also seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with nefazodone may significantly increase the plasma concentrations of HMG-CoA reductase inhibitors that are metabolized by CYP450 3A4 such as atorvastatin, cerivastatin, lovastatin, and simvastatin. The mechanism is decreased clearance due to inhibition of CYP450 3A4 activity by nefazodone. Nefazodone has been reported to increase systemic exposure (AUC) of simvastatin and its pharmacologically active acid metabolite by 20-fold and atorvastatin AUC by 3.4-fold. High levels of HMG-CoA reductase inhibitory activity in plasma is associated with an increased risk of musculoskeletal toxicity. Myopathy manifested as muscle pain and/or weakness associated with grossly elevated creatine kinase exceeding ten times the upper limit of normal has been reported occasionally. Rhabdomyolysis has also occurred rarely, which may be accompanied by acute renal failure secondary to myoglobinuria and may result in death. There have been case reports of patients treated with simvastatin who developed severe myopathy or rhabdomyolysis during coadministration of nefazodone.

MANAGEMENT: Nefazodone should generally not be used in combination with atorvastatin, cerivastatin, lovastatin, simvastatin, and red yeast rice (which contains lovastatin) due to the potential for severe interaction. Fluvastatin, pravastatin, and rosuvastatin are not expected to interact with nefazodone, since they are not metabolized by CYP450 3A4, although pravastatin was cited in a case report of suspected interaction that resulted in asymptomatic increases in creatine kinase levels. All patients receiving statin therapy should be advised to promptly report any unexplained muscle pain, tenderness or weakness, particularly if accompanied by fever, malaise and/or dark-colored urine. Therapy should be discontinued if creatine kinase is markedly elevated in the absence of strenuous exercise or if myopathy is otherwise suspected or diagnosed.

Liptruzet Tablets

Generic Name: atorvastatin / ezetimibe

Brand name: Liptruzet

Synonyms: Liptruzet

What is Liptruzet Tablets?

Serzone

Generic Name: nefazodone

Brand name: Serzone

Synonyms: n.a.

What is Serzone?