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Maalox Advanced Maximum Strength and Tasigna

Determining the interaction of Maalox Advanced Maximum Strength and Tasigna and the possibility of their joint administration.

Check result:

Maalox Advanced Maximum Strength <> Tasigna

Relevance: 24.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Taking the nilotinib and calcium carbonate doses too close together may interfere with the absorption of nilotinib and reduce its effectiveness. To prevent or minimize the interaction, nilotinib and calcium carbonate dosing should be separated by at least two hours. Contact your doctor if your condition worsens. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Antacids significantly decrease the oral bioavailability of nilotinib. The mechanism is decreased solubility of nilotinib due to antacid-induced gastric pH increases. Nilotinib's solubility is pH-dependent and it is insoluble at a pH of 4.5 or higher.

MANAGEMENT: Patients treated with nilotinib should not take antacids or other agents with acid-neutralizing effects for at least 2 hours before or 2 hours after a nilotinib dose.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0

Maalox Advanced Maximum Strength

Generic Name: calcium carbonate / simethicone

Brand name: Alka-Seltzer Heartburn + Gas, Gas-X with Maalox Extra Strength, Maalox Advanced Maximum Strength, Maalox Junior Plus Antigas, Tums Gas Relief Chewy Bites

Synonyms: Calcium Carbonate and Simethicone

What is Maalox Advanced Maximum Strength?

Tasigna

Generic Name: nilotinib

Brand name: Tasigna

Synonyms: n.a.

What is Tasigna?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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