Drug search by name

Nefazodone Hydrochloride and Seldane

Determining the interaction of Nefazodone Hydrochloride and Seldane and the possibility of their joint administration.

Check result:

Nefazodone Hydrochloride <> Seldane

Relevance: 03.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Terfenadine is no longer on the market in the US. Do not take terfenadine with any other medication.

Professional:

CONTRAINDICATED: Nefazodone has been shown in vitro to inhibit CYP450 3A4, the isoenzyme responsible for the metabolism of terfenadine. Accumulation of terfenadine following administration of other drugs that inhibit CYP450 3A4 has resulted in prolonged QT interval and, rarely, serious arrhythmias and death.

MANAGEMENT: Although there have been no clinical reports of adverse events related to the coadministration of nefazodone and terfenadine, the manufacturer of nefazodone considers this combination to be contraindicated.

References

"Product Information. Serzone (nefazodone)." Bristol-Myers Squibb, Princeton, NJ.

Nefazodone Hydrochloride

Generic Name: nefazodone

Brand name: Serzone

Synonyms: Nefazodone

What is Nefazodone Hydrochloride?

Seldane

Generic Name: terfenadine

Brand name: Seldane

Synonyms: n.a.

What is Seldane?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions