Nilotinib and Pantoprazole Delayed-Release Granules

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Pantoprazole may interfere with the absorption of nilotinib when these medications are taken together. This may reduce the blood levels and effects of nilotinib. If possible, avoid taking pantoprazole or similar medications during treatment with nilotinib. Your doctor or pharmacist may be able to recommend alternatives to pantoprazole that do not interact with nilotinib. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Chronic use of proton pump inhibitors may significantly decrease the oral bioavailability of nilotinib. The mechanism is decreased solubility of nilotinib due to increased gastric pH. Nilotinib's solubility is pH dependent and it is insoluble at a pH of 4.5 or higher.

MANAGEMENT: The concomitant use of proton pump inhibitors should generally be avoided during therapy with nilotinib.

Nilotinib

Generic Name: nilotinib

Brand name: Tasigna

Synonyms: n.a.

What is Nilotinib?

Pantoprazole Delayed-Release Granules

Generic Name: pantoprazole

Brand name: Protonix, Protonix IV

Synonyms: Pantoprazole

What is Pantoprazole Delayed-Release Granules?