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Oforta and Pentostatin

Determining the interaction of Oforta and Pentostatin and the possibility of their joint administration.

Check result:

Oforta <> Pentostatin

Relevance: 06.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using fludarabine and pentostatin, this can cause an increased risk of lung toxicity. You may need a dose adjustment or special test if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: The concomitant administration of fludarabine and pentostatin may increase the risk of potentially fatal pulmonary toxicity (interstitial pneumonitis). The mechanism is unknown but may be related to additive pulmonary toxicity.

MANAGEMENT: Concurrent use should be avoided.

References

Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Nipent (pentostatin)." Hospira Inc, Lake Forest, IL.
"Product Information. Fludara (fludarabine)." Berlex, Richmond, CA.

Oforta

Generic Name: fludarabine

Brand name: Oforta, Fludara

Synonyms: n.a.

What is Oforta?

Pentostatin

Generic Name: pentostatin

Brand name: Nipent

Synonyms: n.a.

What is Pentostatin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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