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Phenytoin Capsules and Vermox

Determining the interaction of Phenytoin Capsules and Vermox and the possibility of their joint administration.

Check result:

Phenytoin Capsules <> Vermox

Relevance: 23.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Phenytoin may decrease the plasma mebendazole levels. The mechanism is unknown, but induction of hepatic metabolism has been proposed. Since plasma mebendazole levels vary greatly among patients receiving this drug, the clinical significance of the interaction is not well established.

References

Bekhti A, Pirotte J, Woestenborghs R "A correlation between serum mebendazole concentrations and the aminopyrine breath test: implications in the treatment of hyatid disease." Br J Clin Pharmacol 21 (1986): 223-6
Luder PJ, Siffert B, Witassek F, Meister F, Bircher J "Treatment of hydatid disease with high oral doses of membendazole." Eur J Clin Pharmacol 31 (1986): 443-8

Phenytoin Capsules

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Phenytoin

What is Phenytoin Capsules?

Vermox

Generic Name: mebendazole

Brand name: Vermox, Emverm

Synonyms: n.a.

What is Vermox?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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